Synthesis and Antibacterial Activity ofN-(un)substituted-N-((3,4 Methylenedioxyphenyl)methyl) arylsulfonamides

Sulfonamides belong to an active group with biological activities and these activities can be enhanced by introducing heterocyclic moiety. N-((3,4-methylenedioxyphenyl)methyl) arylsulfonamides (3a-f) were synthesized by gearing up (3,4- methylenedioxyphenyl)methyl amine (1) and arylsulfonyl chlorides (2a-f) in a weak basic aqueous medium. The target molecules, 6a-f and 7a-f were yielded by the reaction of 3a-f with ethyl iodide (4) and 4-flourobenzyl chloride (5) respectively in a weak basic aprotic polar medium. Structural analysis of the synthesized molecules was processed through the spectral data of IR, ¹HNMR, ¹³C-NMR and EIMS. All the synthesized molecules were evaluated for the antibacterial activity and remained moderately better inhibitors.