Valorization of Natural Clay as an Ecological Catalyst in The Regioselective Synthesis of Some Heterocyclic Compounds Based on 1,2,3-Triazoles

Some ecological catalysts were prepared from Tunisian clays; they have been applied in the catalytic coupling reaction of alkynes and azides to prepare bioactive heterocyclic compounds based on 1,2,3-triazoles. Clays used in this work were taken from Jebal Shib (M’dhilla) and Jebal Es Sath (between Gafsa and Metlaoui) in Gafsa at South West of Tunisia. The reaction of terminal alkynes with azides in the presence of studied catalysts was studied for 36 hours at room temperature without solvents and excitements; two isomers (1,4) and (1,5) of 1,2,3-triazoles were obtained. Generally, the (1,4) isomer was obtained with an important proportion if Cu-Pullard clay was used as a catalyst in this synthesis reaction. The studied ecological catalysts were characterized by X-ray diffraction and IR spectroscopy. Heterocyclic triazoles were analyzed by ¹HNMR, ¹³CNMR, Infrared (IR), and Ultraviolet spectroscopy. LC-MS analyses evaluated the molecular masses of synthesized triazoles.