Synthesis and Antibacterial Study of 4-(2-Aminoethyl) morpholine Derivatives

Because of broad spectrum of biological activities bysulfamoyl group, a series of 4-(2-(N-(2-chlorobenzyl/4- bromobenzyl) arylsulfamoyl) ethyl)morpholine, 6a-d/7a-d, have been synthesized from4-(2-aminoethyl)morpholine (1). First step includes the synthesis of4-(2-(arylsulfamoyl) ethyl)morpholine, 3a-d,by reaction of(1) andarylsulfonyl chlorides, 2a-d, in water under definite pH control by 10% Na₂CO₃. In the second step, the molecules 3a-d were converted to 6a-d and 7a-don reaction with 2-chlorobenzyl chloride (4) and 4-bromobenzyl bromide(5), respectively, in DMF in the presence of NaH. Using IR,¹H-NMR and EI-MS spectral records, the proposed molecular structures were verified.The antibacterial activity results showed good inhibitory action against all the bacterial strains of gram-bacteria with a few exceptions like B. subtilis.