Research Article | Open Access

α-Glucosidase Inhibitory Constituents from Ficus bengalensis

    M.A. Naveed

    Department of Chemistry, Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan

    N. Riaz

    Department of Chemistry, Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan

    M. Saleem

    Department of Chemistry, Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan

    B. Jabeen

    Department of Chemistry, Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan

    M. Ashraf

    Department of Biochemistry & Biotechnology, Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan

    U. Alam

    Department of Biochemistry & Biotechnology, Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan

    A. Jabbar

    Department of Chemistry, Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan


Received
07 Mar, 2015
Accepted
22 Sep, 2015
Published
07 Dec, 2015

Chromatographic purification of the methanolic extract of the aerial roots of Ficus bengalensis resulted the purifiaction of 3β-acetoxyurs-9(11),12-diene (1), a new triterpene together with lupeol (2), lupeol acetate (3), conrauidienol (4), β-sitosterol (5), alpinum isoflavone (6), methyl 4-hydroxybenzoate (7), 4-hydroxymellein (8), 4-hydroxybenzoic acid (9), p-coumaric acid (10), oleanolic acid (11) and β-sitosterol 3-O-β-D-glucopyranoside (12). These compounds (1-12) were characterized by using 1D- (1H,13C) and 2D-NMR (HMQC, HMBC, COSY, NOESY) spectroscopy and mass spectrometry (EI-MS, HR-EI-MS, FAB-MS, HRFAB-MS), and in comparison with the data reported for related compounds in literature. These isolates (1-12) showed inhibitory activity against enzyme α-glucosidase with IC50 values ranging between 26.3-297.7 µM.

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APA-7 Style
Naveed, M.A., Riaz, N., Saleem, M., Jabeen, B., Ashraf, M., Alam, U., Jabbar, A. (2015). α-Glucosidase Inhibitory Constituents from Ficus bengalensis. Pakistan Journal of Chemistry, 5(1), 42-49. https://doi.org/10.15228/2015.v05.i01.p07

ACS Style
Naveed, M.A.; Riaz, N.; Saleem, M.; Jabeen, B.; Ashraf, M.; Alam, U.; Jabbar, A. α-Glucosidase Inhibitory Constituents from Ficus bengalensis. Pak. J. Chem. 2015, 5, 42-49. https://doi.org/10.15228/2015.v05.i01.p07

AMA Style
Naveed MA, Riaz N, Saleem M, Jabeen B, Ashraf M, Alam U, Jabbar A. α-Glucosidase Inhibitory Constituents from Ficus bengalensis. Pakistan Journal of Chemistry. 2015; 5(1): 42-49. https://doi.org/10.15228/2015.v05.i01.p07

Chicago/Turabian Style
Naveed, M., A., N. Riaz, M. Saleem, B. Jabeen, M. Ashraf, U. Alam, and A. Jabbar. 2015. "α-Glucosidase Inhibitory Constituents from Ficus bengalensis" Pakistan Journal of Chemistry 5, no. 1: 42-49. https://doi.org/10.15228/2015.v05.i01.p07