Synthesis, Spectral Analysis and Antibacterial Activity of Some new N-Substituted Sulfonamide Derivatives of 1,3-Benzodioxol-5-amine

1,3-Benzodioxol-5-amine(1)was used as a precursor to synthesize N-alkyl/aralkyl-N-(1,3-benzodioxol-5-yl) arylsulfonamide derivatives, 7a-b to 9a-b. The molecule 1 was reacted with arylsulfonyl chlorides, 2a-b,on stirring in a dilute aqueous sodium carbonate solution to synthesize N-(1,3-benzodioxol-5-yl) arylsulfonamide, 3a-b. The molecules, 3a-b, were further stirred with alkyl/aralkyl halides, 4-6, in DMF at RT to get the desired final compounds, 7a-bto 9a-b.The synthesized molecules were structurally confirmed by IR, ¹H-NMR and EIMS spectral data. The antibacterial activity of these compounds rendered them moderately weak inhibitors relative to ciprofloxacin, the reference standard.