Synthesis and Screening of Some New N-Substituted Derivatives of N-(4-Methylpyridin-2-yl) benzenesulfonamides as Potential Antibacterial Agents

The two step synthesis of a series of N-substituted derivatives of N-(4-Methylpyridin-2-yl) benzenesulfonamide with potential antibacterial activity, has been reported. First step includes the synthesis of N-(4-Methylpyridin-2-yl) benzenesulfonamide (3) by reaction of 2-Amino-4-methylpyridine (1) and Benzenesulfonyl chloride (2) in a slightly basic aqueous medium. The molecule 3 was converted to N-Alkyl/aralkyl-N-(4-methylpyridin-2-yl) benzenesulfonamide derivatives, 5a-f, on treatment with alkyl/aralkyl halides, 4a-f, using lithium hydride as activator in N,N-dimethylformamide. The synthesized molecules were well corroborated by 1H-NMR, IR and EI-MS spectral data and evaluated for antibacterial activity against four gram-negative and two gram-positive bacteria. The evaluation results rendered these compounds as moderately good inhibitors and may be employed as therapeutic agent for certain inflammatory ailments.