Synthesis of Some New 2-Mercapto/Hydrizino 5, 6, 7, 8 - Tetrahydro Quinazoline Derivatives as In-Vitro Anthelimentic Agents

A new series of substituted 5, 6, 7, 8 tetrahydro quinazoline derivative has been synthesized from a mixture of methyl/ethylacetoacetate with different substituted aromatic/ hetero aromatic aldehydes. Then treated with aminoguanidines / thiourea afforded 2-hydrizino substituted 5, 6, 7, 8-tetrahydro quinazoline (D_1-8)/ 2-mercapto substituted 5, 6, 7, 8-tetrahydro quinazoline derivatives (E_1-8). The structures of newly synthesized compounds were confirmed by spectral data (IR, H¹NMR, C ¹³NMR, Mass spectra and Elemental analysis).The synthesized compounds were also evaluated for their anthelimentic activity using earth worms of nearly equal size (8 cm±1) were selected randomly for present study and Albendazole was used as reference standard. The compounds which contains Cl and F groups substituted at Para position on phenyl ring at C5 of substituted 5, 6, 7, 8 tetrahydro quinazoline derivatives showed good activity when compared with reference standard.